Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation
نویسندگان
چکیده
منابع مشابه
PTK7 modulates Wnt signaling activity via LRP6.
Protein tyrosine kinase 7 (PTK7) is a transmembrane protein expressed in the developing Xenopus neural plate. PTK7 regulates vertebrate planar cell polarity (PCP), controlling mesodermal and neural convergent-extension (CE) cell movements, neural crest migration and neural tube closure in vertebrate embryos. Besides CE phenotypes, we now show that PTK7 protein knockdown also inhibits Wnt/β-cate...
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The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. (Dab2) inhibits Wnt/\(\beta\)-catenin signalling by binding LRP6 and promoting its internalization through clathrin. Canonical Wnt signalling requires caveolin-dependent internalization of low-density lipoprotein receptor-related protein 6 (LRP6). Here we report that the ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms6455